Publications

2025Research article

Hou C., Zhang H., Deng J., Wang X., Byers S., Levi M., Pak D.T.S., Moremen K.W., Pei H., Hart G.W., Ma J.^*

Comprehensive Evaluation of Cleavable Bioorthogonal Probes for Site-Specific O-GlcNAc Proteomics

Mol Cell Proteomics. 2025;24(10):101064.

DOI PMID 40885482 PMC12506516

2025Research article

Zhang H.^#, Ma J.^#, Hou C., Luo X., Zhu S., Peng Y., Peng C., Li P., Meng H., Xia Y., Jiang Z., Modepalli S., Duttargi A., Kupfer G.M., Cai M., Zhang H., Ma J.^*, Li J.^*, Han S.^*, Pei H.^*

A ROS-Mediated Oxidation-O-GlcNAcylation Cascade Governs Ferroptosis

Nat Cell Biol. 2025;27(8):1288–1300.

DOI PMID 40681752

2025Research article

Hou C., Li W., Li Y., Ma J.^*

O-GlcNAcAtlas 4.0: An Updated Protein O-GlcNAcylation Database with Site-Specific Quantification

J Mol Biol. 2025;437(15):169033.

DOI PMID 39988118

2024Research article

Hou C., Deng J., Wu C., Zhang J., Byers S., Moremen K.W., Pei H., Ma J.^*

Ultradeep O-GlcNAc Proteomics Reveals Widespread O-GlcNAcylation on Tyrosine Residues of Proteins

Proc Natl Acad Sci U S A. 2024;121(47):e2409501121.

DOI PMID 39531497 PMC11588081

2024Research article

Hou C., Wu C., Wu Z., Cheng Y., Li W., Sun H., Ma J.^*

Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics

J Proteome Res. 2024;23(10):4422–4432.

DOI PMID 39302247

2024Research article

Zhang Y., Zhou S., Kai Y., Zhang Y.Q., Peng C., Li Z., Mughal M.J., Julie B., Zheng X., Ma J., Ma C.X., Shen M., Hall M.D., Li S., Zhu W.

O-GlcNAcylation of MITF Regulates Its Activity and CDK4/6 Inhibitor Resistance in Breast Cancer

Nat Commun. 2024;15(1):5597.

DOI PMID 38961064 PMC11222436

2024Research article

Wu C., Zhang S., Hou C., Byers S., Ma J.^*

In-Depth Endogenous Phosphopeptidomics of Serum with Zirconium(IV)-Grafted Mesoporous Silica Enrichment

Anal Chem. 2024;96(21):8254–8262.

DOI PMID 38728223 PMC11140682

2024Research article

Hu F., Li W., Li Y., Hou C., Ma J.^*, Jia C.^*

O-GlcNAcPRED-DL: Prediction of Protein O-GlcNAcylation Sites Based on an Ensemble Model of Deep Learning

J Proteome Res. 2024;23(1):95–106.

DOI PMID 38054441

2024Research article

Chen L., Zhou Q., Zhang P., Tan W., Li Y., Xu Z., Ma J., Kupfer G.M., Pei Y., Song Q., Pei H.^*

Direct Stimulation of De Novo Nucleotide Synthesis by O-GlcNAcylation

Nat Chem Biol. 2024;20(1):19–29.

DOI PMID 37308732 PMC10746546

2023Research article

Zheng S., Que X., Wang S., Zhou Q., Xing X., Chen L., Hou C., Ma J., An P., Peng Y., Yao Y., Song Q., Li J., Zhang P., Pei H.^*

ZDHHC5-Mediated NLRP3 Palmitoylation Promotes NLRP3-NEK7 Interaction and Inflammasome Activation

Mol Cell. 2023;83(24):4570–4585.e7.

DOI PMID 38092000

2023Research article

Wu C., Lei J., Meng F., Wang X., Wong C.J., Peng J., Lin G., Gingras A.C., Ma J.^*, Zhang S.^*

Trace Sample Proteome Quantification by Data-Dependent Acquisition without Dynamic Exclusion

Anal Chem. 2023;95(49):17981–17987.

DOI PMID 38032138 PMC10719888

2022Research article

Li W., Hou C., Li Y., Wu C., Ma J.^*

HexNAcQuest: A Tool to Distinguish O-GlcNAc and O-GalNAc

J Am Soc Mass Spectrom. 2022;33(10):2008–2012.

DOI PMID 36122299

2022Research article

Wu C., Zhou S., Mitchell M.I., Hou C., Byers S., Loudig O., Ma J.^*

Coupling Suspension Trapping-Based Sample Preparation and Data-Independent Acquisition Mass Spectrometry for Sensitive Exosomal Proteomic Analysis

Anal Bioanal Chem. 2022;414(8):2585–2595.

DOI PMID 35181835 PMC9101639

2021Research article

Ma J.^*, Hou C., Li Y., Chen S., Wu C.

OGT Protein Interaction Network (OGT-PIN): A Curated Database of Experimentally Identified Interaction Proteins of OGT

Int J Mol Sci. 2021;22(17):9620.

DOI PMID 34502531 PMC8431785

2021Research article

Ma J.^*, Li Y., Hou C., Wu C.

O-GlcNAcAtlas: A Database of Experimentally Identified O-GlcNAc Sites and Proteins

Glycobiology. 2021;31(7):719–723.

DOI PMID 33442735 PMC8351508

2019Research article

Ma J.^*, Wang W.H., Li Z., Shabanowitz J., Hunt D.F., Hart G.W.

O-GlcNAc Site Mapping by Using a Combination of Chemoenzymatic Labeling, Copper-Free Click Chemistry, Reductive Cleavage, and Electron-Transfer Dissociation Mass Spectrometry

Anal Chem. 2019;91(4):2620–2625.

DOI PMID 30657688 PMC6756848

2016Research article

Ma J., Banerjee P., Whelan S.A., Liu T., Wei A.C., Ramirez-Correa G., McComb M.E., Costello C.E., O'Rourke B., Murphy A., Hart G.W.

Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts

J Proteome Res. 2016;15(7):2254–2264.

DOI PMID 27213235 PMC7814404

2015Research article

Ma J., Liu T., Wei A.C., Banerjee P., O'Rourke B., Hart G.W.

O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

J Biol Chem. 2015;290(49):29141–29153.

DOI PMID 26446791 PMC4705920

2015Research article

Ramirez-Correa G.A., Ma J.^# (co-first author), Slawson C., Zeidan Q., Lugo-Fagundo N.S., Xu M., Shen X., Gao W.D., Caceres V., Chakir K., DeVine L., Cole R.N., Marchionni L., Paolocci N., Hart G.W., Murphy A.M.

Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle

Diabetes. 2015;64(10):3573–3587.

DOI PMID 26109417 PMC4587639

2015Research article

Banerjee P.S., Ma J., Hart G.W.

Diabetes-Associated Dysregulation of O-GlcNAcylation in Rat Cardiac Mitochondria

Proc Natl Acad Sci U S A. 2015;112(19):6050–6055.

DOI PMID 25918408 PMC4434690